The cost of avoidable hospitalisations and disease progression in the United States has reached the unprecedented level of some $290bn per year; in turn these costs translate into suboptimal patient health outcomes and lost revenue. Across the healthcare ecosystem, there is significant focus on medication adherence and patient programmes as a tool that can increase health outcomes, and decrease health system utilisation. For years, multiple healthcare stakeholders have sponsored patient programmes which have collectively sought to drive positive patient behaviours including improved patient wellness and medication adherence. Some leading entities, such as the US Centers for Disease Control and Prevention, University of California at San Francisco and Institute for the Future, estimate that the biggest factors influencing patient compliance and wellness are the healthcare system (10%), patient environments (20%), individual genetics (20%), and behaviour (50%).