Challenges in recruiting and retaining patients for clinical trials continue to delay drug development. There is a need for a more effective method to recruit patients, shorten development timelines, decrease costs, and increase the pace at which new medicines become available to patients. To date, the CTE solution has been successfully used in trials with a complex patient pathway in therapeutic categories that are also highly competitive, including oncology, CNS, and cardio-vascular diseases. CTEs have been highly effective in rescuing trials. This article showcases the effectiveness of Clinical Trial educators in driving patient recruitment and retention in complex trials.