Nasal and bronchial allergies have similar epidemiology, etiology, and mechanisms. These similarities underlie a “one airway” hypothesis viewing allergic rhinitis and allergic asthma as different facets of the same disease. Nasal challenge and sampling thus may sometimes offer a more facile approach to studying mechanisms and pharmacology of the allergic airway than does bronchial challenge and sampling.

Prior work suggests similar Th2-like (IL-5 and IL-13) cytokine and cellular response to nasal and bronchial allergen challenges when patient cohorts are taken in aggregate. However, within individuals, it was unclear whether nasal responses mirror bronchial responses. (i.e. in a given individual, we do not know whether a nasal response to challenge or drug would have been recapitulated had the bronchus been tested.) This study sought to address this question.

 

discordant airway responses poster