Early clinical development (ECD) studies have become increasingly complex and expensive in recent years. One approach to address this is the use of a site network model to ensure we are utilizing the geography and site best suited for a particular study and therapeutic area. This approach allows a blending of timelines, cost, experience, and quality to ensure the best possible solution for our customers. This White Paper discusses lessons learned within the network model and is based on QuintilesIMS’s extensive ECD experience across the Asia-Pacific, European, and North American regions.