With the outbreak of the H1N1 virus or “swine flu” in early 2009, the world held its breath, remembering past problems with production and delivery. The real threat to global health vaccine development has taken center stage on the health front. Dr. Oren Cohen, Chief Medical and Scientific Officer, and Dr. Kelly McKee, Vice President, Public Health and Government Services, offer a detailed look at the history of flu vaccine production and how previous outbreaks set the stage for a comprehensive global response to the H1N1 pandemic. Will the lessons we learned prepare us for the next worldwide pandemic?