The partner will deliver cost-effective, large-scale genomic testing to biopharma

  • PGT’s proprietary technology greatly reduces costs, time for large-scale genomic testing; increases probability of associating genomic variations with clinical outcomes
  • Commercial collaboration part of Quintiles’ ongoing strategy to help bio pharma industry navigate complexity of the New Health landscape

Research Triangle Park, NC and Cambridge, UK – May 16, 2011– Quintiles, the world’s leading bio pharmaceutical services company, and Population Genetics Technologies Ltd. (PGT), creator of innovative solutions to reduce the costs and complexity of large-scale genomic testing and enable correlations with clinical outcomes, today announced a commercial collaboration to bring genomic testing into mainstream drug development in order to produce safer, more effective medicines.

Through the non-exclusive collaboration, Quintiles and PGT will jointly identify opportunities to apply the power of large-scale genomic analyses – using samples from hundreds to thousands of individuals – to test clinical hypotheses and correlate biomarkers of disease prognosis and drug responsiveness. This approach enables the rapid identification of rare and common alleles that collectively account for significant variation in treatment responses.

Such large-scale testing has been prohibitively expensive, as sample preparation, sequencing and analysis have to be undertaken separately for each sample. PGT’s innovative technology can process many hundreds of genomes simultaneously, in a single sequencing assay, while still retaining the ability to identify each individual genome during post-sequencing data analysis.

“PGT’s technology combined with Quintiles’ global presence can bring the benefits of large-scale sequencing and analysis to virtually all biopharmaceutical companies,” said M. King Jolly, Pharm.D., Senior Vice President of Quintiles Innovation. “The combination of Quintiles and PGT’s capabilities can, we believe, increase the probability of success in clinical trials, reduce trial enrollment required to achieve statistical significance, and diminish the costs and/or time required to bring a product to market – all while improving product differentiation.”

PGT Chief Commercial Officer Frank Massam, Ph.D., said: “Our first project with Quintiles is a renal cancer clinical trial to identify genetic markers predictive of both adverse events and efficacy, but our workflows are appropriate to all therapeutic areas. We are currently running programs in breast cancer, leukemia and Alzheimer’s disease. We are proud to be associated with the work that Quintiles is leading to deliver real patient benefits from cutting-edge genomic research.”

Both companies will seek other opportunities to demonstrate to biopharma companies, payers, academic researchers and patient groups the value of this approach to improving human health.

This collaboration further enhances Quintiles’ established capabilities in genomics- and biomarker- based discovery and research. In addition to general genomic analyses provided by Quintiles Global Central Laboratories, Quintiles’ Translational R&D Oncology group offers innovative genomic technologies to drive novel biomarker discovery and support more intelligent, data-driven clinical trial design and implementation for its customers.

About Population Genetics Technologies

Co-founded by Nobel Laureate Dr. Sydney Brenner, Population Genetics Technologies creates products that accelerate large-scale population studies, through the simultaneous analysis of multiple individual genomes. Our proprietary technology replaces initial sample preparation steps for next-generation DNA sequencing, overcoming cost barriers and practical constraints that limit discovery. For more information, please visit

About Quintiles

Quintiles is the only fully integrated bio pharmaceutical services company offering clinical, commercial, consulting and capital solutions worldwide. The Quintiles network of more than 20,000 engaged professionals in 60 countries around the globe works with an unwavering commitment to patients, safety and ethics. Quintiles helps bio pharmaceutical companies navigate risk and seize opportunities in an environment where change is constant. For more information, please visit