In Vitro ADME & Metabolite ID

Quintiles offers drug discovery, in vitro ADME and metabolite identification services. Our Indianapolis, IN-based lab utilizes HPLC, MS/MS, radioprofiling, PCR and in vitro technologies to deliver a range of pre-clinical services.

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Up to 30% faster clinical studies

Quintiles delivers up to 30% faster clinical studies start-up timelines vs. industry benchmark in certain therapeutic areas (2013).

In Vitro Discovery Services

  • Precipitation/solubility screening
  • Metabolite stability
  • CYP inhibition and induction
  • Permeability assays
  • Time dependent inhibition
  • Clearance evaluation
  • Reaction phenotyping

Metabolism Services

  • Metabolite fingerprinting
  • Metabolite profiling
  • In vitro and in vivo metabolism identification
  •  Radioprofiling

Discovery Bioanalytical Services

  • High throughput bioanalytical
  • Blood-brain barrier transport analysis

Our 22,000-sq.ft. Drug Discovery and Metabolism Center of Excellence

  • Seven wet laboratories 
  • Orbitrap, triple quadrapole, time-of-flight, and ion trap mass spectrometry equipment
  • Automated in vitro sample preparation and handling equipment
  • Radioprofiling capabilities

Proof in marketplace

We employ best practices to ensure scientific integrity that sets the bar within the industry.

Related Services

Phase I/IIa Clinical Services