As patients, medical care providers, regulators and policymakers seek additional evidence about the safety and effectiveness of various treatments as used in real-world settings, new study designs are needed to efficiently and effectively address these challenging research questions. While challenges exist, secondary health data such as electronic medical records and health insurance claims are becoming increasingly available to support generation of key evidence. Enriched real-world research studies combine data collected directly from physicians and patients with existing data such as medical records and insurance claims.